2^nd World Congress on Cell and Structural Biology December 2-3, 2019 Manila, Philippines

Systems biology is the study of systems of molecules, cells, tissues, organisms or entire species. Living systems are complex and dynamic, and their behaviour cannot be predicted from the properties of one individual part. This study mainly focuses on multipart interactions within the biological systems, using a complete approach to biological research. This concept has been used widely in biology in a variety of contexts. Human Genome Project is a perfect example of these systems which has led to collective ways of working on problems in the arena of genetics. To model and discover emergent properties is one of the outreaching aims of biology, theoretical description of properties of cells, tissues and organisms functioning as a system are only possible using techniques of systems biology

Structural biology deals with the study of the dynamics, molecular structure of proteins and nucleic acids, and also deals with, in what manner alterations in their structures affect their function. This study includes the principles of biochemistry, Biophysics and Molecular Biology. Most of the biologists have a great attentiveness towards the study, as macromolecules carry out most of the functions of cells, only by coiling into specific three-dimensional shapes by which they can able to perform these functions. The "tertiary structure" of molecules, depends on the molecules' basic composition, or "primary structures." Cell biology deals with the study of structure and function of the cell and mainly focuses on the concept of the cell as the basic unit of life. The study in detail explains the structure and organization of the organelles they contain, and also the physiological properties, Signaling pathways, metabolic processes, life cycle, and interactions with their environment. This study plays a crucial role in the research of bio-medical fields such as cancer, and other diseases. Cell biology research is closely related to different fields which include genetics, molecular biology, biochemistry, developmental biology and immunology

Biophysics deals with the study of physical phenomena & physical processes in spanning molecules, cells, tissues and organisms. The principles and methods of Biophysics are used to understand biological systems. It closely relates to quantitative and systems biology. This research shares significant overlap with physical chemistry, nanotechnology and biochemistry, Bioengineering, computational biology, biomechanics and systems biology. Molecular biophysics deals with the study of the principles prevailing bio molecular systems. It explains biological function like molecular structure, dynamics and organization, from single molecules to supramolecular structures. Structural biology deals with the study of the molecular structure and dynamics of biological macromolecules, mainly proteins and nucleic acids, and how alterations in their structures affect their function. Structural biology includes the principles of molecular biology, biochemistry and biophysics. The aim of structural biology includes developing a comprehensive understanding of the molecular shapes and forms of biological macromolecules and encompassing this knowledge to understand how different molecular architectures are used to perform the chemical reactions

Structural Biochemistry is a subdivision of biochemistry which concentrates on the components, structures and functions of molecules within cells.  Biochemists intention is to describe in molecular terms like structures, mechanisms, and chemical processes, providing organized principles that underlie life in all its diverse forms. It is a subdivision of biochemistry mainly focused on the components, structures and functions of molecules that make up the living organisms. Biochemistry explains the phenomenon of life in chemical terms by using various theories in Chemistry and the laws of Physics. Structural Biochemistry deals with major functions like, to understand molecular architecture of cells and organelles, inclosing membrane structure and dynamics, the control of cell proliferation and also the significance for clinical and veterinary practice of the molecular approach to medical science

Bio-engineering  implies the concepts and methods of biology to resolve problems related to life sciences and the application thereof, using engineering's own analytical and synthetic methodologies.  It is the interface in between engineering and medicine. Biological engineering uses molecular biology to study and advance applications of organisms and to create biotechnology. It improves the performance and also brings down the cost of healthcare technology. Industrial bio-engineering helps for the creation of artificial organs by technical means and also  finds ways of growing organs and tissues by means of regenerative medicine to reduced the lost physiological functions and to develop genetically modified organisms with desired properties (protein engineering, engineering enzymology). It is closely related to biotechnology, nanotechnology and 3D printing.

Chemical biology deals with the study of the chemical reactions which are involved in biological processes, by involving the disciplines of bioorganic chemistry, biochemistry, cell biology and pharmacology.  It includes the application of chemical techniques, tools and analyses the compounds produced through synthetic chemistry, to study and manipulation of biological systems. Chemical biologists use principles to explore the underlying biology or to create a new function. Chemical biology has its roots in medicinal chemistry, supra molecular chemistry (particularly host-guest chemistry), genetics, biochemistry, bioorganic chemistry, pharmacology and metabolic engineering. It combines the fields of molecular imaging, synthetic chemistry and molecular biology to produce novel chemical tools to examine biological systems.    

Computational biology develops and applies computational methods to assay large collections of biological data, like genetic sequences, protein samples and cell populations, to make new predictions.  Computational structural biology  deals with forming bio molecular sequence-structure-function relations using simulations of structure and dynamics and principles of physical sciences in theoretical models. Computational Biology also reports the computational challenges of investigational approaches in structural biology. Computational Structural includes the progress and use of data-analytical mathematical modeling, theoretical methods and computational simulation techniques to the study of biological and social systems. It appeared as a tool for efficient identification of structure and dynamics in many applications. Computational Structural Biology Mainly Focuses on the topics like protein folding, protein-protein, protein-ligand and protein-DNA interactions  protein dynamics and their functional implications. Its Major Applications include   Drug design and protein engineering . Computational structural biology deals with the study of bio molecular structure and dynamics by means of computational methods.

 Rational drug design aims to develop small molecules (drugs) with a therapeutic effect by targeting biomolecules in order to influence their biological function. Structural biology has a diverse arsenal of methods available to study (bio) molecular structures. Information on the shape and possible interaction sites of binding sites on these molecules can be used to design small molecules with high binding affinity. The structural information is a valuable input in different stages of drug development such as lead optimization or drug design. Important starting point in rational drug design is that Structural determination of bio molecules could help as therapeutic target. Soon after knowing the structure of biological target, an impending binding site for drugs and its interactions have to be identified in the period of drug design

Data mining, in simple terms, is the extraction of usable data from large volumes of raw data. It deals with analyzing hidden patterns of data for categorization into useful information. This information is collected and assembled for analysis and data mining algorithms. Data mining combines tools from machine learning and artificial intelligence, statistics (e.g. neural networks), and database management systems. This interdisciplinary sub-discipline of computer science aims to extract information from a raw data set and alter it into a comprehensible structure for further analysis. Apart from the initial raw analysis step, data mining also involves database and data management aspects, data pre-processing, model and inference considerations, interestingness metrics, complexity considerations, post-processing of discovered structures, visualization, and online updating. Data mining (also sometimes called knowledge discovery in databases) is the analytic step of the "knowledge discovery in databases" process, or KDD. Further, the large quantities of data are analyzed automatically or semi-automatically to extract previously unknown patterns such as groups of data records, unusual records, and reliance. Multi-relational data mining tools have been used for a variety of biological studies including proteomic and genomic research. The science of data mining within the realm of bioinformatics is a good addition due to the ever growing and developing biological data. These research areas are extensive and attributes of biological databases put forward great challenges ahead. Improving the accuracy of conclusions drawn from data mining is ever more imperative due to these challenges. Consequently, it is imperative for future directions of research to adapt to the integration of biological databases to provide better methods of research.

Nano engineering is the application protraction of Nanotechnology. It high spots the engineering rather than the pure science aspects. Nanotechnology Engineering is an engineering field, which draws from and its beneficial areas include engineering, materials science and chemistry, biology, medicine and physics. Nanotechnology is the key cause for a variety of revolutionary and evolutionary changes in the medical field. It program examines problems at the interface of engineering, biology, and nanotechnology, by applying  the principles of mechanical engineering to increase opportunities for new science and engineering breakthroughs. We follow experimental and computational strategies to know the physical principles specific to biological phenomena by integrating the engineering fields like fluid flow, dynamics and heat transfer with the scientific fields like biology and chemistry

Neurobiology is basically a multifaceted, covering gene regulation  and molecular biology in neurons which leads to chemical and electrical signaling in neurons and also leads to information processing by neural circuits and brain regions for development and plasticity of nervous system. It deals with the study of cells of nervous system and in what manner the association of these cells leads to functional circuits which process information and mediate behavior. It is the study of cells of brain and nervous system which generates many of the functions like movement, sensation, perception

Stem cells are biological cells that can differentiate into other types of cells and can split to create more of the same type of stem cells. They are found in multicellular organisms. They have potential in the development of therapies for replacing defective or damaged cells resulting from a variety of disorders and injuries Parkinson disease, heart disease, and diabetes. Stem cells discovery widened new possibilities for the treatment of many diseases. The process of renewal of natural fluctuations or events that cause disturbance or damage is called Regeneration.  Regenerative medicine deals with the study of research in the fields of tissue engineering and molecular biology . These fields majorly deal with the "process of replacing or regenerating human cells or organs to restore their normal function". It also includes the opportunity of growing tissues and organs in vitro and placing them when it is needed.

Cardiac Cell Biology deals with the usage of advanced technologies and excessive usage of specialized reagents which allows to study the and understand the cells of the heart to an extraordinary level

 Cancer biology deals with the mechanisms that trigger essential processes such as cell growth, metastasis, of cancer cells. Cancer  biology is studied in many organisms, from the discovery of genes associated with the development of cancer in humans to the explanation of basic cell biological process that gets affected at the time of tumorigenesis. Cancer biology investigation study includes  tumor microenvironment, angiogenesis, apoptosis, metastasis, transcription, invasion,  oncogenes, Cell adhesion, gene expression, cancer stem cells, epithelial-to-mesenchymal transition, , immunotherapy, biomarkers, resistance to therapy and tumor modeling.

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World Congress on Stem Cell Biology and Bio banking, September 3-4, 2018 Tokyo, Japan; 22nd Global Biotechnology Congress, September 10-11, 2018 Stockholm, Sweden; International Epigenetics and Epi transcriptomics Conference, September 13-14, 2018 Dubai, UAE; 6th Annual Congress on Biology and Medicine of Molecules, September 17-18, 2018 Abu Dhabi, UAE; 5th World Congress on Synthetic Biology and Advanced Biomaterials, September 19-20, 2018 Tokyo, Japan; 2nd Annual summit on Cell Signaling and Cancer Therapy, September 19 - 20, 2018 Philadelphia, Pennsylvania, USA; 2nd Annual summit on Cell Metabolism and Cytopathology, September 19 - 20, 2018 Philadelphia, Pennsylvania, USA; International Convention on Biotechnology and Health Care, October 5-6, 2018 Osaka, Japan; 8th World Congress on Plant Genomics and Plant Science, August 10-11, 2018 Osaka, Japan

The study of immune systems in all organisms is known as Immunology . Immunology can be explained as the active response of the body, which is trying to maintain its integrity. An organism can be protected from the infection by its immune system in various lines of defense. Many components of the immune system are typically cellular in nature and not related with any specific organ; but rather are embedded or circulating in various tissues located throughout the body. Classical immunology links with different fields such as epidemiology and medicine. It also assists to study   the   relationship between the body systems, pathogens, and immunity. Clinical immunology is the study of diseases caused by disorders of the immune system. It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features. It is also now becoming clear that immune responses contribute to the development of many common disorders not traditionally viewed as immunologic, including metabolic, cardiovascular, and neurodegenerative conditions such as Alzheimer’s.

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6th International Conference on Integrative Biology, May 21-23, 2018 Barcelona, Spain; 10th International Conference on Genomics and Molecular Biology, May 21-23, 2018 Barcelona, Spain; 12th Annual Conference on Stem Cell and Regenerative Medicine, June 04-06, 2018 Prague, Czech Republic; 13th International Conference on Tissue Engineering & Regenerative Medicine, July 12-13, 2018, Paris, France; Annual Biotechnology Congress, July 23-24, 2018 Vancouver, British Columbia, Canada; 10th Annual Conference on Stem Cell and Regenerative Medicine, October 08-09, 2018 Zurich, Switzerland; 9th International conference on Tissue Science and Regenerative Medicine, August 24-25, 2018 Singapore; World Congress on Organ Transplantation and Artificial Organs, August 24-25, 2018 Tokyo, Japan;

NMR spectroscopy is used to study the dynamics and structure with atomic resolution. The NMR workshop comprises of lectures and practical sessions with matters focusing on Structure Determination of Biomolecules,  identify compounds isolated from natural sources and Checking synthesized substances,  Drug Screening, Protein-DNA, NMR in Proteomics and Metabolomics; Biomarkers, Molecules, Enzymatic Reactions – Kinetics, Drug-Target Protein, Molecular Interactions: Protein-Protein etc… NMR spectroscopy is a prevailing tool to study the dynamics, structure and interactions of biological macromolecules. NMR is useful to monitor frequencies and protein fluctuations which play a major role in their biological function.

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World Congress on Stem Cell Biology and Bio banking, September 3-4, 2018 Tokyo, Japan; 22nd Global Biotechnology Congress, September 10-11, 2018 Stockholm, Sweden; International Epigenetics and Epi transcriptomics Conference, September 13-14, 2018 Dubai, UAE; 6th Annual Congress on Biology and Medicine of Molecules, September 17-18, 2018 Abu Dhabi, UAE; 5th World Congress on Synthetic Biology and Advanced Biomaterials, September 19-20, 2018 Tokyo, Japan; 2nd Annual summit on Cell Signaling and Cancer Therapy, September 19 - 20, 2018 Philadelphia, Pennsylvania, USA; 2nd Annual summit on Cell Metabolism and Cytopathology, September 19 - 20, 2018 Philadelphia, Pennsylvania, USA; International Convention on Biotechnology and Health Care, October 5-6, 2018 Osaka, Japan; 8th World Congress on Plant Genomics and Plant Science, August 10-11, 2018 Osaka, Japan

The growth of the new fields of structural genomics and functional genomics presents us with an unique obtainability of new macromolecules which is so far unknown their functions and the potential of new visions into the mode of action of unharmed organisms. Technical advances made over several decades have allow to  researchers to find out the structures of progressively larger molecules and complexes, including the protein-making ribosome—a molecular behemoth composed of several RNA molecules and dozens of proteins and the target of many antibiotics. Today, scientists are using high-throughput methods to determine protein structures more quickly than ever before. They are also using computational techniques to predict three-dimensional structures of proteins of unknown structure and to design new proteins with useful functions. This work will continue to increase our understanding of the diverse roles molecules play in biology and to spur advances in medicine. We predict the cell as a little universe in which different types of molecular processes occur, summarizing most of the basic processes of life. The cell functions as an operation center, which integrates all the possible “omics” (genomics, epigenomics, transcriptomics, proteomics, metabolomics, glycomics, exposomics, etc.) to generate context-dependent responses that allow cells to adapt and relate to their surrounding milieu. Due to the central role of the cell, the tremendous technological progress and the developments are carried out  in  systems biology, we are now well positioned to study cell biology and genetics as a whole and translate the enormous potential of these findings to all the possible settings

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World Congress on Stem Cell Biology and Bio banking, September 3-4, 2018 Tokyo, Japan; 22nd Global Biotechnology Congress, September 10-11, 2018 Stockholm, Sweden; International Epigenetics and Epi transcriptomics Conference, September 13-14, 2018 Dubai, UAE; 6th Annual Congress on Biology and Medicine of Molecules, September 17-18, 2018 Abu Dhabi, UAE; 5th World Congress on Synthetic Biology and Advanced Biomaterials, September 19-20, 2018 Tokyo, Japan; 2nd Annual summit on Cell Signaling and Cancer Therapy, September 19 - 20, 2018 Philadelphia, Pennsylvania, USA; 2nd Annual summit on Cell Metabolism and Cytopathology, September 19 - 20, 2018 Philadelphia, Pennsylvania, USA; International Convention on Biotechnology and Health Care, October 5-6, 2018 Osaka, Japan; 8th World Congress on Plant Genomics and Plant Science, August 10-11, 2018 Osaka, Japan

Bioethics deals with the study of the ethical issues emerging from advances in biology and medicine. It is also has moral discernment as it relates in the field of  medical policy and practice. Bioethicists are the people which concerned with the ethical questions that give rise in the relationships between different fields of science such as life sciences, biotechnology, medicine, politics, law, and philosophy. It also includes the study of values ("the ethics of the ordinary") which  relates  to primary care and other branches of medicine. The field of bioethics has spokes a broad swathe of human inquiry, ranging from debates over the limits of life (e.g. abortion, euthanasia), substitution, the distribution of rare health care resources (e.g. organ donation, health care rationing) to the right to waste medical care for reason like religious or cultural . Bioethicists used to create a issue among themselves over the specific limits of their discipline, discussed   whether the field would concern itself with the ethical estimation of all questions involved different field like  biology and medicine, or only a subdivision of these questions.[4] Some bioethicists would narrow ethical evaluation only to the morality of medical treatments or technological innovations, and the timing of medical treatment of humans. Others would extend the possibility of ethical evaluation to include the morality of all actions that might help or harm organisms capable of feeling fear.

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6th International Conference on Integrative Biology, May 21-23, 2018 Barcelona, Spain; 10th International Conference on Genomics and Molecular Biology, May 21-23, 2018 Barcelona, Spain; 12th Annual Conference on Stem Cell and Regenerative Medicine, June 04-06, 2018 Prague, Czech Republic; 13th International Conference on Tissue Engineering & Regenerative Medicine, July 12-13, 2018, Paris, France; Annual Biotechnology Congress, July 23-24, 2018 Vancouver, British Columbia, Canada; 10th Annual Conference on Stem Cell and Regenerative Medicine, October 08-09, 2018 Zurich, Switzerland; 9th International conference on Tissue Science and Regenerative Medicine, August 24-25, 2018 Singapore; World Congress on Organ Transplantation and Artificial Organs, August 24-25, 2018 Tokyo, Japan;

Enzymes play a crucial role in signalling the cellular and metabolic pathways. Research works are going on to identify, how the enzymes function at molecular and atomic level by combining the modern biochemistry and structural biology. Methods which are being employed to examine enzyme structure and dynamics include X-ray crystallography, NMR, mass spectroscopy and protein chemistry. On the hand the chemical behavior of these enzyme is being characterized by quick-reaction and fixed-state kinetics, calorimetric, chemical analyses, and a variety of spectroscopies.

A database is an organized collection of data. As a result of huge research which is being done in Structural biology massive data has been produced. In order to collect the data in a catalogued manner, bioinformatics databases are used. Different databases have been formed to collect biological data, such as sequence databases, structure databases, signalling pathway databases, etc.

Drug design is an innovative process to asset new medication based on the knowledge of biological target. Drug is most commonly a small molecule that inhibits or activates the function of a biomolecule, which in turn outcomes in a therapeutic benefit to the patient. Drug design are not essential for relies on computational methods. This kind of modelling is often indicated as computer-assisted drug design. Drug design which depends on the knowledge of the 3D structure of the target is known as structure-based drug design. The main methods available for drug design are structure based drug design and ligand based drug design.

Structural biology focuses at the atomic level for understanding the biomolecules. Most of the aspects of structural biology are complex. Researchers are proving to be successful in solving these complexities like the determination of protein structures, functional annotations and drug designing. Though structures of proteins are explained on a huge scale, the difference between available sequence data and structure data is massive. Bridging this gap is one of the main challenges. In the current research, some of the most complex areas are protein folding, catching the complication of dynamic Nano machines and signaling networks, understanding the intrinsically disordered proteins.