Structural Biology in Drug Discovery

 Rational drug design aims to develop small molecules (drugs) with a therapeutic effect by targeting biomolecules in order to influence their biological function. Structural biology has a diverse arsenal of methods available to study (bio) molecular structures. Information on the shape and possible interaction sites of binding sites on these molecules can be used to design small molecules with high binding affinity. The structural information is a valuable input in different stages of drug development such as lead optimization or drug design. Structural determination of bio molecules could serve as therapeutic target is an important starting point in rational drug design. Once the structure of a biological target is known, a potential binding site for drugs and possible interactions at this site have to be identified in the stage of drug design.

Related Conferences

 3rd International Conference on Lipid Science & Technology December 11-12, 2017 Rome, Italy; Eukaryotic RNA turnover 10 – 13 July 2017 | Oxford, United Kingdom; Nuclear structure and dynamics 04 – 08 October 2017 | L'Isle sur la Sorgue, France; 19th International Conference on Structural Biology Toronto, Canada June 15 - 16, 2017; International Conference on Clinical and Medical Genetics September 21-22, 2017 Toronto, Canada; Annual Summit on Cell Therapy and Molecular Medicine September 27-28, 2017 Chicago, Illinois, USA; Annual Summit on Cell Signaling and Cancer Therapy September 27-28, 2017 Chicago, Illinois, USA; 10th World Congress on Stem Cell and Bio banking

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  • Molecular basis of drug design
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  • Protein crystallography in drug discovery
  • Fragment based drug design
  • Drug design strategies

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